• Neurology · Aug 2014

    Dementia with Lewy bodies: basis of cingulate island sign.

    • Jonathan Graff-Radford, Melissa E Murray, Val J Lowe, Bradley F Boeve, Tanis J Ferman, Scott A Przybelski, Timothy G Lesnick, Matthew L Senjem, Jeffrey L Gunter, Glenn E Smith, David S Knopman, Clifford R Jack, Dennis W Dickson, Ronald C Petersen, and Kejal Kantarci.
    • From the Departments of Neurology (J.G.-R., B.F.B., D.S.K., R.C.P.) and Radiology (V.J.L., C.R.J., K.K.), Division of Biomedical Statistics and Informatics (S.A.P., T.G.L.), and Departments of Information Technology (M.L.S., J.L.G.) and Psychiatry and Psychology (G.E.S.), Mayo Clinic, Rochester, MN; and Departments of Pathology and Laboratory Medicine (M.E.M., D.W.D.) and Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
    • Neurology. 2014 Aug 26; 83 (9): 801-9.

    ObjectivesTo investigate clinical, imaging, and pathologic associations of the cingulate island sign (CIS) in dementia with Lewy bodies (DLB).MethodsWe retrospectively identified and compared patients with a clinical diagnosis of DLB (n=39); patients with Alzheimer disease (AD) matched by age, sex, and education (n=39); and cognitively normal controls (n=78) who underwent 18F-fluorodeoxyglucose (FDG) and C11 Pittsburgh compound B (PiB)-PET scans. Among these patients, we studied those who came to autopsy and underwent Braak neurofibrillary tangle (NFT) staging (n=10).ResultsPatients with a clinical diagnosis of DLB had a higher ratio of posterior cingulate to precuneus plus cuneus metabolism, cingulate island sign (CIS), on FDG-PET than patients with AD (p<0.001), a finding independent of β-amyloid load on PiB-PET (p=0.56). Patients with CIS positivity on visual assessment of FDG-PET fit into the group of high- or intermediate-probability DLB pathology and received clinical diagnosis of DLB, not AD. Higher CIS ratio correlated with lower Braak NFT stage (r=-0.96; p<0.001).ConclusionsOur study found that CIS on FDG-PET is not associated with fibrillar β-amyloid deposition but indicates lower Braak NFT stage in patients with DLB. Identifying biomarkers that measure relative contributions of underlying pathologies to dementia is critical as neurotherapeutics move toward targeted treatments.© 2014 American Academy of Neurology.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…