• Leslie A Aaron, Lester M Arguelles, Suzanne Ashton, Megan Belcourt, Richard Herrell, Jack Goldberg, Wayne R Smith, Debra Buchwald, and Dedra Buchwald.
• Department of Oral Medicine, University of Washington, Seattle, Washington 98195, USA. laaron@u.washington.edu
• J Rheumatol. 2002 Nov 1; 29 (11): 2426-34.

ObjectiveTo examine the independent effects of chronic regional and widespread pain syndromes on health and functional status after accounting for comorbid chronic fatigue using a co-twin control design.MethodsWe identified 95 twin pairs discordant for pain in which one twin had chronic regional or widespread pain and the other denied chronic pain. Demographic data, functional and psychological status, health behaviors, and symptoms based on the 1994 criteria for chronic fatigue syndrome (CFS) were assessed by questionnaire. Psychiatric diagnoses were based on structured interview. Random effects regression modeling estimated associations between chronic regional and widespread pain and each health measure with and without adjustment for CFS.ResultsSignificant differences (p ConclusionBoth chronic regional and widespread pain exact debilitating effects on perceived general health, physical functioning, and sleep quality independent of CFS. However, the psychological and psychiatric influence of chronic pain appears closely tied to CFS. Research should examine the additive role of CFS-like illnesses in patients with chronic pain, and its influence on treatment and outcome.

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