• Eur J Clin Nutr · Oct 2006

    Randomized Controlled Trial

    Vitamin B6 supplementation increases immune responses in critically ill patients.

    • C-H Cheng, S-J Chang, B-J Lee, K-L Lin, and Y-C Huang.
    • Critical Care and Respiratory Therapy, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China. ych@csmu.edu.tw
    • Eur J Clin Nutr. 2006 Oct 1; 60 (10): 1207-13.

    ObjectiveTo investigate whether vitamin B6 supplementation has a beneficial effect on immune responses in critically ill patients.DesignA single-blind intervention study.SettingThe study was performed at the Taichung Veterans General Hospital, the central part of Taiwan.SubjectsFifty-one subjects who stayed over 14 days in the intensive care unit completed the study. Subjects were not treated with any vitamin supplement before the intervention.InterventionsPatients were randomly assigned to one of three groups, control (n = 20), a daily injection of 50 mg vitamin B-6 (B6 -50, n=15), or 100 mg vitamin B-6 (B6 -100, n = 16) for 14 days.Main Outcome MeasuresPlasma pyridoxal 5'-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (4-PA), erythrocyte alanine (EALT-AC) and aspartate (EAST-AC) aminotransaminase activity coefficient, and urinary 4-PA were measured. The levels of serum albumin, hemoglobin, hematocrit, high-sensitivity C-reactive protein (hs-CRP) and immune responses (white blood cell, neutrophils, total lymphocytes count (TLC), T- (CD3) and B-(CD19) lymphocytes, T-helper (CD4) and suppressor (CD8) cells) were determined.ResultsPlasma PLP, PL, 4-PA and urinary 4-PA concentrations significantly increased in two treated groups. T-lymphocyte and T-helper cell numbers and the percentage of T-suppressor cell significantly increased on day 14 in the B6 -50 group. Total lymphocyte count, T-helper and T-suppressor cell numbers, the percentage of T-lymphocyte cells and T-suppressors significantly increased in the B6 -100 group at the 14th day. There were no significant changes with respect to immune responses in the control group over 14 days.ConclusionsA large dose of vitamin B6 supplementation (50 or 100 mg/day) could compensate for the lack of responsiveness of plasma PLP to vitamin B6 intake, and further increase immune response of critically ill patients.SponsorshipThis study was supported by the National Science Council, Taiwan, Republic of China (NSC-92-2320-B-040-026).

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