• Qiuyu Wang, Qingneng Li, Rui Mi, Hai Ye, Heye Zhang, Baodong Chen, Ye Li, Guodong Huang, and Jun Xia.
• Department of Radiology, Shenzhen Second People's Hospital, Shenzhen Second Hospital Clinical Medicine College of Anhui Medical University, Shenzhen, China.
• J Magn Reson Imaging. 2019 Mar 1; 49 (3): 825-833.

BackgroundAccurate classification of gliomas is crucial for prescribing therapy and assessing the prognosis of patients.PurposeTo develop a radiomics nomogram using multiparametric MRI for predicting glioma grading.Study TypeRetrospective.PopulationThis study involved 85 patients (training cohort: n = 56; validation cohort: n = 29) with pathologically confirmed gliomas.Field Strength/Sequence1.5T MR, containing contrast-enhanced T1 -weighted (CET1 WI), axial T2 -weighted (T2 WI), and apparent diffusion coefficient (ADC) sequences.AssessmentA region of interest of the tumor was delineated. A total of 652 radiomics features were extracted and were reduced using least absolute shrinkage and selection operator regression.Statistical TestingRadiomic signature, participant's age, and gender were analyzed as potential predictors to perform logistic regression analysis and develop a prediction model of glioma grading, and a radiomics nomogram was used to represent this model. The performance of the nomogram was assessed in terms of discrimination, calibration, and clinical value in glioma grading.ResultsThe radiomic signature was significantly associated with glioma grade (P < 0.001) in both the training and validation cohorts. The performance of the radiomics nomogram derived from three MRI sequences (with C-index of 0.971 and 0.961 in the training and validation cohorts, respectively) was improved compared to those based on either CET1 WI, T2 WI, or ADC alone in glioma grading (with C-index of 0.914, 0.714, 0.842 in the training cohort, and 0.941, 0.500, 0.730 in the validation cohort). The nomogram derived from three sequences showed good calibration: the calibration curve showed good agreement between the estimated and the actual probability. The decision curve demonstrated that combining three sequences had more favorable clinical predictive value than single sequence imaging.Data ConclusionWe created and assessed a multiparametric MRI-based radiomics nomogram that may help clinicians classify gliomas more accurately.Level Of Evidence4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:825-833.© 2018 International Society for Magnetic Resonance in Medicine.

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