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Pediatric dermatology · May 2008
Case ReportsThe use of naltrexone in the management of severe generalized pruritus in biliary atresia: report of a case.
- Yuchi Chang and Linda Golkar.
- Department of Dermatology, Loma Linda University Medical Center, Loma Linda, California, USA.
- Pediatr Dermatol. 2008 May 1; 25 (3): 403-4.
AbstractGeneralized pruritus secondary to cholestasis is a difficult dermatologic condition to treat. We present a case of a 17-month-old child with congenital biliary atresia with generalized pruritus refractory to treatment with oral antihistamines, topical steroids, cholestyramine, and rifampin but improved remarkably with the addition of naltrexone. Naltrexone is a well-tolerated medication with little adverse effects. We believe that naltrexone may be an effective adjuvant treatment in the management of cholestatic pruritus in the pediatric population.
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