• Paul Flechsig, Olena Hural, Michael Kreuter, Martin Eichhorn, Gudula HEUßEL, Christos Sachpekidis, Hans-Ulrich Kauczor, Uwe Haberkorn, Claus Peter Heussel, and Monika Eichinger.
• Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany paul.flechsig@med.uni-heidelberg.de.
• In Vivo. 2018 Nov 1; 32 (6): 1457-1462.

Background/AimIdiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF.Patients And MethodsPatients with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computer tomography (FDG-PET/CT) results before lobectomy for LC with and without (n=10 each) signs of ILD in initial imaging and after-care CT were retrospectively analyzed. FDG uptake was calculated as the maximum standardized uptake value (SUVmax) in the lung periphery divided by the SUVmax of the mediastinal blood pool (rSUVmax). Regional increase of fibrosis and ground-glass features in lobe-based CT analysis was used as standard reference.ResultsPatients with LC with ILD presented a significantly higher rSUVmax of 0.57 compared to patients without ILD with rSUVmax 0.47 (p<0.001).ConclusionrSUVmax seems to be a valuable imaging surrogate in predicting patients with LC with increased risk for progressive ILD associated with thoracic surgery.Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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