• Rev. Inst. Med. Trop. Sao Paulo · Mar 2006

    Case Reports

    Chronic disseminated histoplasmosis with lesions restricted to the mouth: case report.

    • Antonio Carlos F do Valle, Luiz Carlos Moreira, Rodrigo Almeida-Paes, João S Moreira, Cláudia V Pizzini, Mauro de Medeiros Muniz, and Rosely M Zancopé-Oliveira.
    • Department of Infectious Diseases, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. afvalle@ipec.fiocruz.br
    • Rev. Inst. Med. Trop. Sao Paulo. 2006 Mar 1; 48 (2): 113-6.

    AbstractWe report a rare case of chronic disseminated histoplasmosis with several ulcerated lesions in the oral cavity in an alcoholic patient without human immunodeficiency virus infection, with no detectable signs and symptoms of systemic disease or extraoral manifestations. Histopathological analysis revealed chronic inflammatory process with granulomas containing Histoplasma-like organisms. The isolation of Histoplasma capsulatum provided the definitive diagnosis. Treatment with itraconazole resulted in complete remission of oral lesions. As far we aware, this is the second case report of oral histoplasmosis in an HIV negative patient described in Brazil.

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