• Expert Rev Respir Med · Jan 2016

    Review

    Molecular phenotyping and biomarker development: are we on our way towards targeted therapy for severe asthma?

    • Laura De Ferrari, Alessandra Chiappori, Diego Bagnasco, Anna Maria Riccio, Giovanni Passalacqua, and Giorgio Walter Canonica.
    • a Allergy and Respiratory Diseases, IRCCS San Martino-IST , University of Genoa , Genoa , Italy.
    • Expert Rev Respir Med. 2016 Jan 1; 10 (1): 29-38.

    AbstractAlthough different phenotypes of severe asthma can be identified, all are characterized by common symptoms. Due to their heterogeneity, they exhibit differences in pathogenesis, etiology and clinical responses to therapeutic approaches. The identification of distinct molecular phenotypes to define severe asthmatic patients will allow us to better understand the pathophysiology of the disease and thus to more precisely target the treatment for each patient. To achieve this goal, a systematic search for new, reliable and stable biomarkers specific for each phenotype is essential. This review focuses on the current known molecular phenotypes of severe asthma and highlights the need for biomarkers that could (either alone or in combination) be predictive of the treatment outcome.

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