• Man-Suk Hwang, Hye-Yoon Lee, Jin-Hyun Lee, Tae-Young Choi, Jung-Han Lee, Youn-Seok Ko, Sung-Youl Choi, and Tae-Yong Park.
• Third Division of Clinical Medicine, School of Korean Medicine, Pusan National University.
• Medicine (Baltimore). 2019 Apr 1; 98 (14): e15098.

IntroductionChemotherapy-induced peripheral neuropathy (CIPN) occurs in approximately 30% to 40% of patients who receive chemotherapy; however, standardized treatment for CIPN has not yet been developed. Acupuncture is widely used to treat CIPN in Korea, but its efficacy has not been investigated. The purpose of this study is to review the current literature on the efficacy of acupuncture and electroacupuncture (EA) in treating CIPN.Materials And MethodsWe will perform a literature review using the relevant databases, including MEDLINE, Embase, the Allied and Complementary Medicine Databases (AMED), and China National Knowledge Infrastructure (CNKI), as well as Korean databases, including the National Digital Science Library (NDSL), Oriental Medicine Advanced Searching Integrated System (OASIS), DBpia, and Korean studies Information Service System (KISS). Randomized controlled trials describing treatment of CIPN symptoms with acupuncture or EA will be included. The primary outcomes will be scores on a visual analog scale and a numeric rating scale for neuropathic pain. We will also assess the risk of bias by evaluating the available studies using the tools of the Cochrane Collaboration and carry out a meta-analysis.Ethics And DisseminationEthical approvals and patient consent are not necessary because the meta-analysis will be based on published research. We will submit our meta-analysis to a peer-reviewed journal for publication.Prospero Registration NumberCRD42018111509.

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