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Nihon Kyobu Shikkan Gakkai Zasshi · Dec 1997
Case Reports[A case of Sairei-to-induced pneumonitis diagnosed by lymphocyte stimulation test of bronchoalveolar lavage fluid].
- T Maeno, M Ubukata, Y Maeno, T Suga, M Motegi, N Takayanagi, M Takahashi, and R Nagai.
- Department of Internal Medicine, Tano General Hospital, Fujioka, Japan.
- Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Dec 1; 35 (12): 1347-51.
AbstractA 51-year-old woman was admitted with fever, cough and dyspnea. She had been taking Sairei-to, a traditional Chinese medicine, for 2 months. On admission, chest X-ray revealed a ground-glass appearance in the lung fields bilaterally and serum LDH was elevated. A differential cell count of the bronchoalveolar lavage fluid (BALF) showed that lymphocytes were increased, with a decreased ratio of CD4/CD8 cells. A lymphocyte stimulation test (LST) for Sairei-to using the lymphocytes in BALF was a positive, although a test of peripheral blood was negative. Sairei-to-induced pneumonitis was diagnosed based on the clinical course, laboratory findings, BALF cell analysis and LST of BALF. Only 4 cases of pneumonitis due to Sairei-to have been reported. This case suggests that LST of BALF is useful for diagnosing drug-induced pneumonitis.
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