• Neuroscience letters · Oct 2004

    Comparative Study

    Astrocytic and neuronal biochemical markers in the sera of subjects with diabetes mellitus.

    • Meri R Hovsepyan, Michael J Haas, Anna S Boyajyan, Astghik A Guevorkyan, Ashot A Mamikonyan, Susan E Myers, and Arshag D Mooradian.
    • Department of Internal Medicine, Saint Louis University Medical School, Saint Louis, MO 63104, USA. mery@mb.sci.am
    • Neurosci. Lett. 2004 Oct 21; 369 (3): 224-7.

    AbstractTo determine if clinical diabetes is associated with disruption of the blood-brain barrier (BBB) and/or brain injury, enzyme-linked immunoassays and Western blots were used to measure serum levels of S100B, NSE and their auto-antibodies in type 1 and type 2 diabetic subjects. Serum S100B concentrations in type 2 diabetic subjects, but not in type 1 diabetic subjects, were significantly lower than those found in healthy controls. There were no significant differences in serum NSE levels of either type 1 or type 2 diabetics compared to healthy controls. However, there was a significant increase in antibodies to NSE in both type 1 and type 2 diabetic subjects compared to controls, whereas diabetics and controls had equally very low levels of anti S100B auto-antibodies. These studies suggest that diabetes in humans may be associated with alterations in the BBB integrity that allow the emergence of antibodies against neuronal antigens.

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