• Akhilesh Singh, Ravindra Kumar Garg, Amita Jain, Hardeep Singh Malhotra, Shantanu Prakash, Rajesh Verma, and Praveen Kumar Sharma.
• Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
• J. Neurol. Sci. 2015 Aug 15; 355 (1-2): 180-5.

BackgroundSolitary cysticercus granuloma (SCG) of the brain is the most common type of neurocysticercosis in India. In this study, we evaluated TLR4 polymorphisms in patients with SCG.MethodsOne-hundred-forty-three patients with SCG and 134 controls were enrolled. Assessment for TLR4 Asp299Gly and Thr399Ile polymorphism was done. TLR4 genotype was determined by PCR-sequencing chain termination method. The patients were followed for 6 months.ResultsAsp/Gly (P=0.024) and Thr/Ile (P=0.004) genotypes were significantly associated with the SCG. The Gly (Asp/Gly plus Gly/Gly) genotype (P=0.025) and Ile (Thr/Ile plus Ile/Ile) genotype (P=0.008) were significantly associated with the SCG. Gly/Gly and Ile/Ile genotypes were not significantly associated with SCG (P=0.767 for Gly/Gly, P=0.936 for Ile/Ile). At 6 months, TLR4 299Asp/Gly (P=0.02) and 399Ile/Thr (P=0.023) polymorphisms were significantly associated with the calcification or persistence of SCG.ConclusionsTLR4 polymorphisms are associated with the susceptibility to infection with SCG.Copyright © 2015 Elsevier B.V. All rights reserved.

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