• Feng Li, Jing Xiang, Ting Wu, Donglin Zhu, and Jingping Shi.
• Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Jiangsu, People's Republic of China.
• Clin Neurophysiol. 2016 Aug 1; 127 (8): 2855-2861.

ObjectiveThe aim of this study is to quantitatively assess the resting-state brain activity in migraine patients during the headache-free phase with magnetoencephalography (MEG).MethodsA total of 25 migraine patients during the headache-free phase and 25 gender- and age-matched control patients were studied with a whole-head MEG system at eyes-closed resting-state. MEG data were analyzed in multifrequency range of 4-200Hz.ResultsIn a regional cortex analysis, the spectral power of gamma oscillations in left frontal and left temporal regions was significantly increased in migraine patients as compared to controls (all p<0.001), but no significant difference was found between the two groups for the global channels. Analyses of source location showed that there were significant differences in the distribution of gamma oscillation between migraine subjects and controls (p<0.025).ConclusionsMigraine patients in resting-state had altered brain activities in spectral power value and source distribution that can be detected and analyzed by MEG.SignificanceAbnormal brain activities in the left frontal and temporal regions may be involved in pain modulation and processing of migraine. These findings provide new insights into the possible mechanisms of migraine attacks.Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

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