• Marie Janaillac, Thierry P Beausoleil, Keith J Barrington, Marie-Josée Raboisson, Oliver Karam, Mathieu Dehaes, and Anie Lapointe.
• Department of Pediatrics, Division of Neonatology, CHU Sainte-Justine, University of Montreal, 3175 chemin de la Côte Sainte-Catherine, Montréal, Qc, H3T 1C5, Canada.
• Eur. J. Pediatr. 2018 Apr 1; 177 (4): 541-550.

AbstractHaemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty newborns born at < 28 weeks of gestation were continuously monitored with CrSO2 and preductal PI. Cardiac output was measured at H6, H24, H48, and H72. The median gestational age and birth weight were 25.0 weeks (24-26) and 750 g (655-920), respectively. CrSO2 and preductal PI had r values < 0.35 with blood gases, lactates, haemoglobin, and mean blood pressure. Cardiac output significantly increased over the 72 h of the study period. Fifteen patients had at least one episode of low left and/or right ventricular output (RVO), during which there was a strong correlation between CrSO2 and superior vena cava (SVC) flow (at H6 (r = 0.74) and H24 (r = 0.86)) and between PI and RVO (at H6 (r = 0.68) and H24 (r = 0.92)). Five patients had low SVC flow (≤ 40 mL/kg/min) at H6, during which PI was strongly correlated with RVO (r = 0.98).

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