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- Johanna Decorps, Jean Louis Saumet, Pascal Sommer, Dominique Sigaudo-Roussel, and Berengere Fromy.
- Laboratory of Tissue Biology and Therapeutic Engineering, Centre National de la Recherche Scientifique (CNRS) UMR 5305, Lyon, France; University of Lyon 1, UMR 5305, Lyon, France. Electronic address: johannadecorps@hotmail.com.
- Ageing Res. Rev. 2014 Jan 1; 13: 90-9.
AbstractWith advancing age, a decline in the main sensory modalities including touch sensation and perception is well reported to occur. This review mainly outlines the peripheral components of touch perception highlighting ageing influences on morphological and functional features of cutaneous mechanical transducers and mechanosensitive ion channels, sensory innervation, neurotransmitters and even vascular system required to ensure efferent function of the afferent nerve fibres in the skin. This, in conjunction with effect of ageing on the skin per se and central nervous system, could explain the tactile deficit seen among the ageing population. We also discuss appropriate tools and experimental models available to study the age-related tactile decline. Copyright © 2013 Elsevier B.V. All rights reserved.
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