• Current oncology reports · Nov 2018

    Review

    Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.

    • Ronnyson Susano Grativvol, Wagner Cid Palmeira Cavalcante, Castro Luiz Henrique Martins LHM Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil., Ricardo Nitrini, and Mateus Mistieri Simabukuro.
    • Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil.
    • Curr Oncol Rep. 2018 Nov 10; 20 (11): 92.

    AbstractThe disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.

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