• Qiong Gao, Fang Yuan, Xi-Ai Yang, Ji-Wen Zhu, Lu Song, Li-Jie Bi, Ze-Yu Jiao, Xiao-Gang Kang, Fang Yang, and Wen Jiang.
• Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
• CNS Neurosci Ther. 2020 Jan 1; 26 (1): 21-29.

AimsTo develop and validate a novel score for prediction of 3-month functional outcome in neurocritically ill patients.MethodsThe development of the novel score was based on two widely used scores for general critical illnesses (Acute Physiology and Chronic Health Evaluation II, APACHE II; Simplified Acute Physiology Score II, SAPS II) and consideration of the characteristics of neurocritical illness. Data from consecutive patients admitted to neurological ICU (N-ICU) between January 2013 and June 2016 were used for the validation. The modified Rankin Scale (mRS) was used to evaluate 3-month functional outcomes. APACHE II scores, SAPS II scores, and our novel scores at 24 hours and 72 hours in N-ICU were obtained. We compared the prognostic performance of our score with APACHE II and SAPS II.ResultsWe developed a 44-point scoring system named the INCNS score, and it includes 19 items which were categorized into five parts: inflammation (I), nutrition (N), consciousness (C), neurological function (N), and systemic function (S). We validated the INCNS score with a cohort of 941 N-ICU patients. The 72-hours INCNS score achieved an area under the receiver operating characteristic curve (AUC) of 0.828 (95% CI: 0.802-0.854), and the 24-hours INCNS score achieved an AUC of 0.788 (95% CI: 0.759-0.817). The INCNS score exhibited significantly better discriminative and prognostic performance than APACHE II and SAPS II at both 24 hours and 72 hours in N-ICU.ConclusionWe developed an INCNS score with superior predictive power for functional outcome of neurocritically ill patients.© 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

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