• Rheumatol. Int. · Jan 2000

    Case Reports

    Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis.

    • M Meissner, Y Sherer, Y Levy, H Chwalinska-Sadowska, P Langevitz, and Y Shoenfeld.
    • Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
    • Rheumatol. Int. 2000 Jan 1; 19 (5): 199-201.

    AbstractThe use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.

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