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Case Reports
Flexion contractures of the legs as the initial manifestation of adrenocortical insufficiency.
- Takao Odagaki, Yoshinori Noguchi, and Tsuguya Fukui.
- Department of General Medicine, Kyoto University Hospital, Kyoto.
- Intern. Med. 2003 Aug 1; 42 (8): 710-3.
AbstractA 51-year-old woman presented with flexion contractures of the legs. Physical examination showed decreased passive movements of the bilateral hip and knee joints without muscle spasms or neurological abnormalities. Laboratory evaluation showed no response of ACTH or plasma cortisol to stimulation with CRH or insulin. Diagnosis of isolated adrenocorticotropic hormone deficiency was made. The patient was started on prednisolone 5 mg daily, and flexion contractures of the legs rapidly disappeared. Although the musculoskeletal manifestation of this patient is similar to that of stiff-person syndrome, flexion contracture of the legs associated with adrenocortical insufficiency seems to be a separate disease entity from stiff-person syndrome.
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