• Shuo Li, Hua-dan Xue, Yan Jiang, Wei-bo Xia, Hong-li Jing, Li-bo Chen, Fei Sun, and Zheng-yu Jin.
• Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
• Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Oct 1; 34 (5): 437-42.

ObjectiveTo compare the accuracy of whole body diffusion weighted magnetic resonance imaging (WB-DWI) with that of somatostatin receptor scintigraphy (SRS) in the detection and localization of the lesions in patients with oncogenic osteomalacia (OOM).MethodsTotally 6 patients with clinically suspected oncogenic osteomalacia were enrolled. All of them underwent WB-DWI and SRS within 2 weeks to evaluate the possible presence of tumors that lead to osteomalacia. Surgical and pathological findings were considered as the gold standard. The sensitivity, specificity, and accuracy were calculated.ResultsPathology confirmed the diagnosis of two soft tissue tumors (including 1 angiolipoma and 1 mesenchymal tumor) and one bone tumor of malignant neurofibroma. The sensitivity, specificity, and accuracy in the identification of lesions in patients with oncogenic osteomalacia were 33.33%, 100%, 66.67% for WB-DWI and 33.33%, 66.67%, 50% for SRS (P>0.05).ConclusionFor adult patients with osteomalacia, WB-DWI and SRS can provide mutually supportive data and be used for identifying potential oncogenic osteomalacia.

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