• Psychosomatics · May 2008

    Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism.

    • Michael E Geisser, Cathy Strader Donnell, Frank Petzke, Richard H Gracely, Daniel J Clauw, and David A Williams.
    • Chronic Pain and Fatigue Research Center, Dept. of Internal Medicine, Div. of Rheumatology, Univ. of Michigan, Ann Arbor, MI 48108, USA. mgeisser@med.umich.edu
    • Psychosomatics. 2008 May 1; 49 (3): 235-42.

    BackgroundSomatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS).ObjectiveAuthors investigated a potential shared pathologic mechanism: a generalized perceptual abnormality where there is heightened responsiveness to varied sensory stimulation, including pain.MethodA composite measure of sensory sensitivity was created and compared with measures of somatic symptoms, comorbid psychological disturbances, and self-reported physical functioning in 38 patients with FM and/or CFS.ResultsSensory amplification influenced physical functioning indirectly through pain intensity, and physical symptoms and fatigue also independently contributed to physical functioning.ConclusionSensory amplification may be an underlying pathophysiologic mechanism in these disorders that is relatively independent of depression and depressive symptoms.

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