• Diabetes Res. Clin. Pract. · Oct 2018

    In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring.

    • Hanaa Abokaf, Ilana Shoham-Vardi, Ruslan Sergienko, Daniella Landau, and Eyal Sheiner.
    • Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel; Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    • Diabetes Res. Clin. Pract. 2018 Oct 1; 144: 231-235.

    BackgroundGestational diabetes mellitus (GDM) is a worldwide public health problem. Few studies investigated the association of intra uterine exposure to GDM and long-term endocrine morbidity of offspring.ObjectiveTo assess whether in utero exposure to GDM increases the risk for long-term endocrine morbidity of the offspring.MethodsA retrospective cohort study was conducted including all singleton born to women who delivered between 1988 and 2014. All births occurred in a tertiary medical center. Data were collected from the computerized perinatal database of the obstetrics and gynecology department and the computerized hospitalization database. The exposure variables were: diet-controlled GDM (GDMA1) and treated GDM (GDMA2). Multivariate generalized estimating equation (GEE) logistic regression model analysis was used to control for confounders and for maternal clusters.ResultsDuring the study period 231,271 deliveries met the inclusion criteria, of which 12,642 deliveries (5.4%) were diagnosed with GDM. During the follow-up period, children exposed in utero to GDM had a higher rate of long- term hospitalizations with diagnoses of endocrine morbidity (such as diabetes mellitus and obesity) compared to those unexposed. Using a GEE model, controlling for confounders such as maternal age, follow up-time, obesity and birthweight, in-utero exposure to GDMA1 (adjusted OR = 2.1; 95% CI 1.7-2.7; P < 0.001) and especially to GDMA2 (adjusted OR = 3.1; 95% CI 2.2-4.4, P < 0.001) were found as risk factors for long-term endocrine disease during childhood.ConclusionExposure to GDM is a risk factor for long-term endocrine morbidity in the offspring.Copyright © 2018 Elsevier B.V. All rights reserved.

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