• Drugs in context · Jan 2020

    Editorial

    A brief note on randomized controlled trials and compassionate/off-label use of drugs in the early phases of the COVID-19 pandemic.

    • Matteo Bassetti, Paolo Pelosi, Chiara Robba, Antonio Vena, and Daniele Roberto Giacobbe.
    • Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS, Genoa, Italy.
    • Drugs Context. 2020 Jan 1; 9.

    AbstractRandomized controlled trials (RCTs) are the best way to find effective and acceptable safe treatments for COVID-19 and any possible future outbreak. However, caution is needed when comparing the number of participants in RCTs with that of patients with COVID-19 treated with compassionate and/or off-label drugs to support the hypothesis that the latter are preferred by clinicians as an alternative to the former.Copyright © 2020 Bassetti M, Pelosi P, Robba C, Vena A, Giacobbe DR.

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