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- Menno van Lookeren Campagne, Erich C Strauss, and Brian L Yaspan.
- Department of Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: menno@gene.com.
- Immunobiology. 2016 Jun 1; 221 (6): 733-9.
AbstractThe complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD.Copyright © 2015 The Authors. Published by Elsevier GmbH.. All rights reserved.
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