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J. Matern. Fetal. Neonatal. Med. · Dec 2018
Systematic review seeking erythropoietin role for neuroprotection in neonates with hypoxic ischemic encephalopathy: presently where do we stand.
- Bhawandeep Garg, Deepak Sharma, and Anju Bansal.
- a Department of Neonatology , Surya Children's Medicare Pvt. Ltd , Mumbai , India.
- J. Matern. Fetal. Neonatal. Med. 2018 Dec 1; 31 (23): 3214-3224.
BackgroundHypoxic ischemic encephalopathy (HIE) is one of the leading causes of neonatal mortality in developing countries and leads to some form of neuro-developmental disability in latter part of life.AimsThe aim of this study is to evaluate the role of erythropoietin (EPO) in neuroprotection for term newborn having HIE.MethodThe literature search was done for various trials by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of science, Scopus, Index Copernicus, and other database.ResultsA total of nine studies fulfilled inclusion criteria. EPO has shown to cause reduction in death and disability, better long-term neuro-developmental outcome, improvement in EEG, and reduction in risk of cerebral palsy.ConclusionEPO treatment has neuroprotective effects against moderate/severe HIE and improves long-term behavioral neurological developments in neonates.
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