• Yeye Guo, Minxue Shen, Xu Zhang, Yi Xiao, Shuang Zhao, Mingzhu Yin, Wenbo Bu, Yan Wang, Xiang Chen, and Juan Su.
• Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
• J. Med. Internet Res. 2020 Sep 11; 22 (9): e22288.

BackgroundThe outbreak of COVID-19 has profoundly influenced people's lifestyles; these impacts have varied across subgroups of people. The pandemic-related impacts on the health outcomes of people with dermatological conditions are unknown.ObjectiveThe aim of this paper was to study the association of COVID-19 pandemic-related impacts with health-related quality of life in patients with skin diseases.MethodsThis was a cross-sectional study among Chinese patients with skin diseases. A self-administered web-based questionnaire was distributed through social media. Demographic and clinical data and pandemic-related impacts (isolation status, income changes, and employment status) were collected. The main outcomes included perceived stress (Visual Analog Scale), symptoms of anxiety (Generalized Anxiety Disorder-7) and depression (9-Item Patient Health Questionnaire), quality of life (Dermatology Life Quality Index), and health utility mapping based on the EQ-5D-3L descriptive system. Multivariable logistic regression was used to investigate the associations.ResultsA total of 506 patients with skin diseases completed the survey. The mean age of the patients was 33.5 years (SD 14.0), and 217/506 patients (42.9%) were male. Among the 506 respondents, 128 (25.3%) were quarantined, 102 (20.2%) reported unemployment, and 317 (62.6%) reported decrease or loss of income since the pandemic. The pandemic-related impacts were significantly associated with impaired mental well-being and quality of life with different effects. Unemployment and complete loss of income were associated with the highest risks of adverse outcomes, with increases of 110% to 162% in the prevalence of anxiety, depression, and impaired quality of life.ConclusionsIsolation, income loss, and unemployment are associated with impaired health-related quality of life in patients with skin diseases during the COVID-19 pandemic.©Yeye Guo, Minxue Shen, Xu Zhang, Yi Xiao, Shuang Zhao, Mingzhu Yin, Wenbo Bu, Yan Wang, Xiang Chen, Juan Su. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 11.09.2020.

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