• Anirban Sengupta, Anandh K Ramaniharan, Rakesh K Gupta, Sumeet Agarwal, and Anup Singh.
• Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
• J Magn Reson Imaging. 2019 Oct 1; 50 (4): 1295-1306.

BackgroundGlioma grading between intermediate grades (Grade II vs. III and Grade III vs. IV) as well as multiclass grades (Grade II vs. III vs. IV) is challenging and needs to be addressed.PurposeTo develop an artificial intelligence-based methodology for glioma grading using T1 perfusion parameters and volume of tumor components, and validate the efficacy of the methodology by grading on a cohort of glioma patients.Study TypeRetrospective.PopulationThe development set consisted of 53 glioma patients and validation consisted of 13 glioma patients.Field Strength/SequenceConventional MRI images (2D T1 -W, dual PD-T2 -W, and 3D FLAIR) and 3D T1 perfusion MRI data obtained at 3 T.AssessmentEnhancing and nonenhancing components of glioma were segmented out and combined to form the region of interest (ROI) for glioma grading. Prominent vessels were removed from the selected ROI. Different T1 perfusion parameters from the ROI were combined with volume of tumor components to form the feature set for glioma grading. Optimization was carried out for selection of the statistic of the T1 perfusion parameters and the features to be used for glioma grading using sequential feature selection and random forest-based feature selection method. An optimized support vector machine (SVM) classifier was used for glioma grading.Statistical TestsMean ± SD, analysis of variance (ANOVA) followed by the Tukey-Kramer test, ROC analysis.ResultsClassification error for Grade II vs. III was 3.7%, for Grade III vs. IV was 5.26%, and for Grade II vs. III vs. IV was 9.43% using the proposed methodology. The mean of the values above the 90th percentile value of T1 perfusion parameters provided a maximum area under the curve (AUC) for intermediate grade differentiation. Random forest obtained optimal feature set provided better grading results than other methods using the SVM classifier.Data ConclusionIt was feasible to achieve low classification error for intermediate as well as multiclass glioma grading using an SVM classifier based on optimized features obtained from T1 perfusion MRI and volumes of tumor components.Level Of Evidence4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1295-1306.© 2019 International Society for Magnetic Resonance in Medicine.

31 keywords...

hide…