• J. Nucl. Med. · Apr 2011

    Comparative Study

    18F-FDG PET/CT and 123I-metaiodobenzylguanidine imaging in high-risk neuroblastoma: diagnostic comparison and survival analysis.

    • Nikolaos D Papathanasiou, Mark N Gaze, Kevin Sullivan, Matthew Aldridge, Wendy Waddington, Ahmad Almuhaideb, and Jamshed B Bomanji.
    • Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom.
    • J. Nucl. Med. 2011 Apr 1; 52 (4): 519-25.

    UnlabelledThe aim of our study was to evaluate prospectively the diagnostic performance and prognostic significance of (18)F-FDG PET/CT in comparison with (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging in patients with high-risk neuroblastoma.MethodsTwenty-eight patients with refractory or relapsed high-risk neuroblastoma (16 male and 12 female patients; age range, 2-45 y; median age, 7.5 y) were simultaneously evaluated with (18)F-FDG PET/CT and (123)I-MIBG imaging before treatment with high-dose (131)I-MIBG. We compared the 2 methods in mapping tumor load, according to the extent of disease and intensity of positive lesions identified in each patient. Separate comparisons were performed for the soft-tissue and bone-bone marrow components of tumor burden. Survival analysis was performed to assess the prognostic significance of (18)F-FDG and (123)I-MIBG imaging parameters.Results(18)F-FDG PET/CT results were positive in 24 of 28 (86%) patients, whereas (123)I-MIBG imaging results were positive in all patients. (18)F-FDG was superior in mapping tumor load in 4 of 28 (14%) patients, whereas (123)I-MIBG was better in 12 of 28 (43%) patients. In the remaining 12 (43%) patients, no major differences were noted between the 2 modalities. (18)F-FDG PET/CT missed 5 cases of bone-bone marrow disease, 4 cases of soft-tissue disease, and 6 cases of skull involvement that were positive on (123)I-MIBG scans. Cox regression and Kaplan-Meier survival curves showed that the group of patients (4/28) in whom (18)F-FDG was superior to (123)I-MIBG had a significantly lower survival rate than the others. Tumoral avidity for (18)F-FDG (maximum standardized uptake value) and extent of (18)F-FDG-avid bone-bone marrow disease were identified as adverse prognostic factors.Conclusion(123)I-MIBG imaging is superior to (18)F-FDG PET/CT in the assessment of disease extent in high-risk neuroblastoma. However, (18)F-FDG PET/CT has significant prognostic implications in these patients.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…