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- Akihiro Yokoyama, Akiko Kada, Akiko M Saito, Morio Sawamura, Takuya Komeno, Kazutaka Sunami, and Naoki Takezako.
- Division of Hematology, Department of Internal Medicine, NHO Tokyo Medical Center, Tokyo 152-8902, Japan.yokoyama.akihirosa@mail.hosp.go.jp.
- Acta Med Okayama. 2019 Dec 1; 73 (6): 547-552.
AbstractElderly multiple myeloma (MM) patients, who are generally ineligible for transplantation, have high risks of death and treatment discontinuation, and require a regimen incorporating novel agents that balance safety, tolerability, and efficacy. We evaluated alternating bortezomib-dexamethasone and lenalidomide-dexamethasone treatments administered over a 63-day cycle in transplant-ineligible elderly patients with newly diagnosed MM. Subcutaneous bortezomib 1.3 mg/m2 was administered weekly on Days 1, 8, 15, and 22; oral lenalidomide 15 mg daily on Days 36-56; and oral dexamethasone 20 mg on Days 1, 8, 15, 22, 36, 43, 50, and 57 for 6 cycles. The primary endpoint was the overall response rate.
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