• European radiology · Aug 2016

    Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease.

    • Koji Kamagata, Taku Hatano, Ayami Okuzumi, Yumiko Motoi, Osamu Abe, Keigo Shimoji, Kouhei Kamiya, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Nobutaka Hattori, and Shigeki Aoki.
    • Department of Radiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. kkamagat@juntendo.ac.jp.
    • Eur Radiol. 2016 Aug 1; 26 (8): 2567-77.

    ObjectivesWe used neurite orientation dispersion and density imaging (NODDI) to quantify changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease (PD).MethodsDiffusion-weighted magnetic resonance images were acquired from 58 PD patients and 36 age- and sex-matched controls. The intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia were compared between groups. Multivariate logistic regression analysis determined which diffusion parameters were independent predictors of PD. Receiver operating characteristic (ROC) analysis compared the diagnostic accuracies of the evaluated indices. Pearson coefficient analysis correlated each diffusional parameter with disease severity.ResultsVic in the contralateral SNpc and putamen were significantly lower in PD patients than in healthy controls (P < 0.00058). Vic and OD in the SNpc and putamen showed significant negative correlations (P < 0.05) with disease severity. Multivariate logistic analysis revealed that Vic (P = 0.0000046) and mean diffusivity (P = 0.019) in the contralateral SNpc were the independent predictors of PD. In the ROC analysis, Vic in the contralateral SNpc showed the best diagnostic performance (mean cutoff, 0.62; sensitivity, 0.88; specificity, 0.83).ConclusionNODDI is likely to be useful for diagnosing PD and assessing its progression.Key Points• Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique • NODDI estimates neurite microstructure more specifically than diffusion tensor imaging • By using NODDI, nigrostriatal alterations in PD can be evaluated in vivo • NOODI is useful for diagnosing PD and assessing its disease progression.

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