• Matteo Ippoliti, Lisa C Adams, Brenner Winfried, Bernd Hamm, Pascal Spincemaille, Yi Wang, and Marcus R Makowski.
• Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
• J Magn Reson Imaging. 2018 Nov 1; 48 (5): 1410-1420.

BackgroundQuantitative susceptibility mapping (QSM) is an MRI postprocessing technique that allows quantification of the spatial distribution of tissue magnetic susceptibility in vivo. Contributing sources include iron, blood products, calcium, myelin, and lipid content.PurposeTo evaluate the reproducibility and consistency of QSM across clinical field strengths of 1.5T and 3T and to optimize the contrast-to-noise ratio (CNR) at 1.5T through bandwidth tuning.Study TypeProspective.SubjectsSixteen healthy volunteers (10 men, 6 women; age range 24-37; mean age 27.8 ± 3.2 years).Field Strengths/Sequences1.5T and 3T systems from the same vendor. Four spoiled gradient echo (SPGR) sequences were designed with different acquisition bandwidths.AssessmentQSM reconstruction was achieved through a nonlinear morphology-enabled dipole inversion (MEDI) algorithm employing L1 regularization. CNR was calculated in seven regions of interest (ROIs), while reproducibility and consistency of QSM measurements were evaluated through voxel-based and region-specific linear correlation analyses and Bland-Altman plots.Statistical TestsInterclass correlation, Wilcoxon rank sum test, linear regression analysis, Bland-Altman analysis, Welch's t-test.ResultsCNR analysis showed a statistically significant (P < 0.05) increase in four out of seven ROIs for the lowest bandwidth employed with respect to the highest (25.18% increase in CNR of caudate nucleus). All sequences reported an excellent correlation across field strength and bandwidth variation (R ≥ 0.96, widest limits of agreement from -18.7 to 25.8 ppb) in the ROI-based analysis, while the correlation was found to be good for the voxel-based analysis of averaged maps (R ≥ 0.90, widest limits of agreement from -9.3 to 9.1 ppb).Data ConclusionCNR of QSM images reconstructed from 1.5T acquisitions can be enhanced through bandwidth tuning. MEDI-based QSM reconstruction demonstrated to be reproducible and consistent both across field strengths (1.5T and 3T) and bandwidth variation.Level Of Evidence1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1410-1420.© 2018 International Society for Magnetic Resonance in Medicine.

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