• Keita Tagami, Takashi Kawaguchi, Tomofumi Miura, Takuhiro Yamaguchi, Yoshihisa Matsumoto, Yuki Sumazaki Watanabe, Yuko Uehara, Ayumi Okizaki, Akira Inoue, Tatsuya Morita, and Hiroya Kinoshita.
• Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. keita.tagami.d7@tohoku.ac.jp.
• Support Care Cancer. 2020 Oct 1; 28 (10): 4737-4743.

PurposeThe aim of study was to explore the potential association between patient's self-reported physical symptom management goals as personalized symptom goal (PSGs) and health-related quality of life (HRQOL) in cancer patients. The secondary outcome was to investigate the relationship between number of physical symptoms not achieving the PSGs and HRQOL in cancer patients.MethodsThis single-center prospective observational study comprised 140 consecutive outpatients. We evaluated the PSGs and HRQOL using the Functional Assessment of Cancer Therapy-General (FACT-G). Patients were administered a self-report questionnaire, including reports on their physical symptom intensity and PSGs using Edmonton Symptom Assessment System-revised (ESAS-r) scores. We investigated the correlation between PSGs achievement (ESAS-r score ≤ PSG score) and FACT-G total scores, and relationship between and number of physical symptoms not achieving the PSGs (ESAS-r score > PSG score) and FACT-G total scores.ResultsThe patients who did not achieve PSGs of pain, tiredness, lack of appetite, and shortness of breath had a lower FACT-G total score (p < 0.05). Multivariate linear regression showed that higher number of physical symptoms not achieving the PSGs correlated with lower FACT-G scores (decreasing by 1.826 points for each such symptom, p < 0.01). Predictors of increased number of physical symptoms not achieving the PSGs were younger age and a higher symptom intensity of anxiety.ConclusionPSGs achievement was associated with HRQOL in cancer patients. Additionally, the number of unachieved PSGs were independent determinant of poor HRQOL, particularly in younger cancer patients and those with higher symptom intensity of anxiety.

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