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  • Pulm Pharmacol Ther · Feb 2013

    Review

    Emerging mediators of airway smooth muscle dysfunction in asthma.

    • Behzad Yeganeh, Connie Xia, Hesam Movassagh, Cynthia Koziol-White, Ying Chang, Laila Al-Alwan, Jane E Bourke, and Brian G G Oliver.
    • Department of Physiology, Manitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
    • Pulm Pharmacol Ther. 2013 Feb 1; 26 (1): 105-11.

    AbstractPhenotypic changes in airway smooth muscle are integral to the pathophysiological changes that constitute asthma - namely inflammation, airway wall remodelling and bronchial hyperresponsiveness. In vitro and in vivo studies have shown that the proliferative, secretory and contractile functions of airway smooth muscle are dysfunctional in asthma. These functions can be modulated by various mediators whose levels are altered in asthma, derived from inflammatory cells or produced by airway smooth muscle itself. In this review, we describe the emerging roles of the CXC chemokines (GROs, IP-10), Th17-derived cytokines (IL-17, IL-22) and semaphorins, as well as the influence of viral infection on airway smooth muscle function, with a view to identifying new opportunities for therapeutic intervention in asthma.Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

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