• Ranjana Khetarpal, Joginder Pal Attri, Amrita Banerjee, and Renu Verma.
• Department of Anesthesia, Government Medical College, Amritsar, Punjab, India.
• Anesth Essays Res. 2018 Apr 1; 12 (2): 371-376.

IntroductionIn the past, many wash-in schemes have been used with initially high fresh gas flow (FGF) to achieve the necessary alveolar concentration of inhalational agent in 10-15 min. This study was designed to show whether 1-1-12 wash-in scheme proposes an earlier achievement of induction or is there any requirement of high FGF phase to know the time taken for induction with and without nitrous oxide (N2O).AimsThe aim of the study was to find out the time required for the alveolar concentration of desflurane to be from 1% to 6% with and without N2O.DesignIt was a potential randomized study which was conducted on sixty patients admitted for elective surgery.Materials And MethodsTwo groups of thirty patients each were made and randomly assigned. Group N received desflurane with N2O plus oxygen and Group A received desflurane with air plus oxygen.Statistical AnalysisThe observations were noted and evaluated accordingly. Analysis was done using unpaired t-test.ResultsHemodynamic parameters were almost similar in both the groups. In Group N, gradual FAD (Alveolar Desflurane concentration, i.e., end-tidal desflurane) from 1% to 6% was achieved at 0.5, 1, 1.5, 2, 3, and 4 min. In Group A, the same was achieved at 0.6, 1, 1.5, 2, 3, and 4 min (P > 0.05). No significant difference was found between the recuperation time and score in both the groups. Rather complications were more in Group N and statistically significant for nausea and vomiting.ConclusionTime taken to attain FAD from 1% to 6% was 4 min in both the groups. It is concluded that the recitation of 1-1-12 wash-in scheme is autonomous on the use of N2O and high FGF phase.

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