• J. Infect. Chemother. · Aug 2016

    Comparison of initial stream urine samples and cervical samples for detection of human papillomavirus.

    • Mao Hagihara, Yuka Yamagishi, Koji Izumi, Narimi Miyazaki, Takayoshi Suzuki, Hideo Kato, Naoya Nishiyama, Yusuke Koizumi, Hiroyuki Suematsu, and Hiroshige Mikamo.
    • Department of Clinical Infectious Diseases, Aichi Medical University, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
    • J. Infect. Chemother. 2016 Aug 1; 22 (8): 559-62.

    BackgroundUterine cervical cancer is a treatable and preventable cancer. Medical efforts to reduce rates of cervical cancer focus on the promotion of human papillomavirus (HPV) vaccination and the promotion of routine cervical cancer screening done by cervical cytology and cervical HPV testing. Urine-based HPV testing would be simple and noninvasive approach to screen for cervical cancer.MethodsTwo biospecimens (clinician-taken sample from cervix and initial stream urine sample) were provided from a total of 240 healthy women attending for cancer screening provided for HPV testing. We have assessed the HPV detection rates among cervical samples and pellet fraction of urine samples using HPV test (Anyplex™ II HPV28 Detection kit, Seegene, Korea).ResultsAmong 240 samples screened, HPV prevalence was 42.9% in pellet fractions of urine samples. The agreement between the two kinds of samples was 98.4%, k = 0.792. Discordant results were observed in 27 cases; 5 were positive only by urine samples and 22 were positive only by smear samples. Sensitivity and specificity for all HPV DNA in pellet fractions of urine using cervical samples as reference was 68.4% and 99.9%.ConclusionsComparing methodologies of collection of samples for HPV detection, they showed the higher agreements for almost genotypes between cervical samples and pellet fractions of urine samples. These results suggest that urine could be a good noninvasive tool to monitor HPV infection in women. Additional research in a larger and general screening population would be needed.Copyright © 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

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