• W W Andrews, R L Goldenberg, B Mercer, J Iams, P Meis, A Moawad, A Das, J P Vandorsten, S N Caritis, G Thurnau, M Miodovnik, J Roberts, and D McNellis.
• National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, the University of Alabama at Birmingham, Birmingham, AL 35249-7333, USA.
• Am. J. Obstet. Gynecol. 2000 Sep 1; 183 (3): 662-8.

ObjectiveThis study was undertaken to determine the association between genitourinary tract infection with Chlamydia trachomatis and spontaneous preterm birth.Study DesignGenitourinary tract infection with C trachomatis was determined with a ligase chain reaction assay of voided urine samples collected at 24 weeks' gestation (22 weeks' to 24 weeks 6 days' gestation) and 28 weeks' gestation (27 weeks' to 28 weeks 6 days' gestation). Case patients (spontaneous preterm birth at <37 weeks' gestation; n = 190) and control subjects (delivery at >/=37 weeks' gestation, matched for race, parity, and center; n = 190) were selected from 2929 women enrolled in the Preterm Prediction Study of the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.ResultsGenitourinary C trachomatis infection (11% overall) was significantly more common among the case patients than among the control subjects at 24 weeks' gestation (15.8% vs 6.3%; P =.003) but not at 28 weeks' gestation (12.6% vs 10.9%; P =.61). Women with chlamydia infection were more likely to have bacterial vaginosis (57.1% vs 32.9%; P =.002) and a short cervical length (ConclusionGenitourinary C trachomatis infection at 24 weeks' gestation was associated with a 2-fold to 3-fold increased risk of subsequent spontaneous preterm birth.

29 keywords...

hide…