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Int. J. Clin. Pract. · Dec 2002
Randomized Controlled Trial Clinical TrialTolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain.
- N Moore, J M Le Parc, E van Ganse, R Wall, H Schneid, and R Cairns.
- Department of Pharmacology, University Victor Segalen, Bordeaux, France.
- Int. J. Clin. Pract. 2002 Dec 1; 56 (10): 732-4.
AbstractThis double-blind randomised study compared the tolerability of ibuprofen (up to 1.2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815). The main outcome was the rate of significant adverse events (SGAE). Rates of SGAE for ibuprofen, aspirin and paracetamol were respectively 12.0%, 15.7% and 12.3%. Ibuprofen was significantly better tolerated than aspirin (p = 0.02) and had comparable tolerability with paracetamol. The latter was also true for total digestive system events and for abdominal pain and dyspepsia. In conclusion, in patients with CF/ST, ibuprofen used at over-the-counter doses is as well tolerated as paracetamol and much better tolerated than aspirin.
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