• Susairaj Priscilla, Arun Nanditha, Mary Simon, Krishnamoorthy Satheesh, Sathish Kumar, Ananth Samith Shetty, Chamukuttan Snehalatha, Desmond G Johnston, Ian F Godsland, Nicholas J Wareham, and Ambady Ramachandran.
• India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals, Chennai 600008, India.
• Diabetes Res. Clin. Pract. 2015 Dec 1; 110 (3): 335-40.

AimsWe describe a two-step screening approach using non-invasive risk assessment and glycated hemoglobin (HbA1c) to identify participants for a diabetes prevention trial.MethodsA total of 6030 non-diabetic persons of 35-55 years were screened using risk assessment for diabetes. Those with three or more risk factors were screened using point of care HbA1c test. For this study, participants in HbA1c categories of 6.0% (42.1 mmol/mol)-6.4% (46.4 mmol/mol) were selected and their characteristics were analyzed.ResultsAmong 6030 persons, 2835 (47%) had three or more risk factors for diabetes. Among those screened with HbA1c, 43.2% (1225) had HbA1c values of <6.0% (42.1 mmol/mol), 46.8% (1327) had HbA1c values between 6.0% (42.1 mmol/mol) and ≤ 6.4% (46.4 mmol/mol) and 10% (283) had undiagnosed diabetes with ≥6.5% (47.5 mmol/mol). Positive family history was present in 53.2%, 81.7% were obese and 14.8% were overweight.ConclusionsOpportunistic screening using a two-step approach: diabetes risk profile and HbA1c measurement detected a large percentage of individuals with prediabetes. Prediabetic persons recruited to the trial had higher percentage of obesity and presence of positive family history than those who had lower HbA1c values. Outcomes from this trial will enable comparisons with the previous prevention studies that used blood glucose levels as the screening criteria.Copyright © 2015. Published by Elsevier Ireland Ltd.

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