• Ronny Knol, Emma Brouwer, Alex S N Vernooij, Klumper Frans J C M FJCM http://orcid.org/0000-0002-6181-306X Department of Obstetrics, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, The , Philip DeKoninck, Stuart B Hooper, and Arjan B Te Pas.
• Division of Neonatology, Department of Paediatrics, Erasmus University Medical Centre, Rotterdam, Zuid-Holland, The Netherlands.
• Arch. Dis. Child. Fetal Neonatal Ed. 2018 Sep 1; 103 (5): F493-F497.

AbstractFetal to neonatal transition is characterised by major pulmonary and haemodynamic changes occurring in a short period of time. In the international neonatal resuscitation guidelines, comprehensive recommendations are available on supporting pulmonary transition and delaying clamping of the cord in preterm infants. Recent experimental studies demonstrated that the pulmonary and haemodynamic transition are intimately linked, could influence each other and that the timing of umbilical cord clamping should be incorporated into the respiratory stabilisation. We reviewed the current knowledge on how to incorporate cord clamping into stabilisation of preterm infants and the physiological-based cord clamping (PBCC) approach, with the infant's transitional status as key determinant of timing of cord clamping. This approach could result in optimal timing of cord clamping and has the potential to reduce major morbidities and mortality in preterm infants.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

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