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- Kunio Iwatsuka, Daiichiro Kikuta, Hitoshi Shibuya, Masahiro Ogawa, Takuji Gotoda, Mitsuhiko Moriyama, Hiroshi Nakagawara, Akihiro Hemmi, and Kenji Yamao.
- Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine Graduate School of Medicine, Japan.
- Intern. Med. 2021 Dec 1; 60 (23): 374337483743-3748.
AbstractA 57-year-old woman with a sudden-onset seizure was hospitalized. Brain magnetic resonance imaging findings led to a suspicion of leptomeningeal carcinomatosis (LMC) without a brain parenchymal tumor, and abdominal computed tomography showed a tumor in the pancreatic tail. Endoscopic ultrasonography-guided fine needle aspiration of the pancreatic mass revealed adenocarcinoma. Therefore, LMC from pancreatic ductal adenocarcinoma was strongly suspected. She received three courses of nab-paclitaxel plus gemcitabine and whole-brain radiation. Shortly thereafter, she developed a severe consciousness impediment and died. A pathological autopsy showed adenocarcinoma in a wide area of the leptomeninges.
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