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Case Reports
Retrobulbar Optic Neuritis Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma.
- Keita Kawakado, Tomoki Tamura, Masamoto Nakanishi, Go Makimoto, and Shoichi Kuyama.
- Department of Respiratory Medicine, National Hospital Organization Iwakuni Clinical Center, Japan.
- Intern. Med. 2021 Dec 15; 60 (24): 3941-3945.
AbstractPembrolizumab is a monoclonal antibody with anti-tumor effects. Only a few reports have previously described retrobulbar optic neuritis induced by pembrolizumab. We herein report the case of a 63-year-old man with advanced lung adenocarcinoma who received cisplatin, pemetrexed, and pembrolizumab combination therapy for six months. Following treatment, a visual field test showed a left central scotoma. Imaging studies showed left optic neuritis without brain metastasis. Blood tests showed an elevated serum creatinine level. He was diagnosed with retrobulbar optic neuritis and pembrolizumab-induced renal failure. After receiving corticosteroid treatment, his renal function rapidly improved. The optic neuritis improved somewhat, but it was not adequately resolved.
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