• Rev Esp Med Nucl Imagen Mol · May 2016

    Patterns of 11C-PIB cerebral retention in mild cognitive impairment patients.

    • I Banzo, J F Jiménez-Bonilla, I Martínez-Rodríguez, R Quirce, M de Arcocha-Torres, Z Bravo-Ferrer, C Lavado-Pérez, P Sánchez-Juan, E Rodríguez, M Jiménez-Alonso, J López-Defilló, and J M Carril.
    • Department of Nuclear Medicine, Molecular Imaging Group (IDIVAL), Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain. Electronic address: mnubmj@humv.es.
    • Rev Esp Med Nucl Imagen Mol. 2016 May 1; 35 (3): 171-4.

    ObjectiveTo evaluate the patterns of cerebral cortical distribution of (11)C-PIB in patients with mild cognitive impairment (MCI).Material And MethodsThe study included 69 patients (37 male, age range 42-79 years) with MCI, sub-classified as 53 with amnestic-MCI (A-MCI), and 16 with non-amnestic-MCI (NA-MCI). Patients underwent (11)C-PIB PET/CT scan 60min after intravenous injection of the radiotracer. A visual analysis of the images was performed by 2 experienced physicians. (11)C-PIB-positive studies were considered when gray matter uptake was equal to or greater than white matter. According to the regions involved, (11)C-PIB-positive studies were classified into A-pattern (predominant retention in frontal, anterior cingulate, lateral temporal, and basal ganglia) and B-pattern (generalized retention).ResultsThirty-nine of the 69 (56%) patients with MCI showed (11)C-PIB retention. Of the 53 A-MCI patients, 36 (68%) showed (11)C-PIB retention. Eleven out of 36 (30%) positive scans in A-MCI patients showed A-pattern, and 25 out of 36 (70%) patients had a B-pattern. Positive (11)C-PIB was observed in 3 out of 16 (19%) patients with NA-MCI. Regional distribution in these 3 patients showed A-pattern in 1, and B-pattern in 2 patients.ConclusionCortical retention of (11)C-PIB was more frequent in A-MCI than in NA-MCI patients, and also B-pattern than A-pattern in the (11)C-PIB positive group. The recognition of (11)C-PIB distribution patterns allows MCI patients to be classified, and the A-pattern may offer a therapeutic window for potential future treatments.Copyright © 2015 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

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