• Immunology · Feb 2020

    Review

    Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms.

    • Petros Fessas, Lucia A Possamai, James Clark, Ella Daniels, Cathrin Gudd, Benjamin H Mullish, James L Alexander, and David J Pinato.
    • Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
    • Immunology. 2020 Feb 1; 159 (2): 167-177.

    AbstractImmune checkpoint inhibition with monoclonal antibodies is becoming increasingly commonplace in cancer medicine, having contributed to a widening of therapeutic options across oncological indications. Disruption of immune tolerance is the key mechanism of action of checkpoint inhibitors and although immune-related adverse events are a typical class effect of these compounds, the relationship between toxicity and response is not fully understood. Awareness and vigilance are paramount in recognizing potentially life-threatening toxicities and managing them in a timely manner. In this review article, we provide an overview of the clinical features, pathological findings and management principles of common immune-related toxicities, attempting to provide mechanistic insight into an increasingly common complication of cancer therapy.© 2019 John Wiley & Sons Ltd.

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