• Masakuni Noguchi, Mitsuharu Earashi, Hisatake Fujii, Koichi Yokoyama, Ken-ichi Harada, and Koichi Tsuneyama.
• Surgical Center, Kanazawa University Hospital, School of Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. nogumasa@med.kanazawa-u.ac.jp
• J Surg Oncol. 2006 Feb 1; 93 (2): 120-8.

BackgroundWith the growing demand from patients for less-invasive procedures, the shift from surgical extirpation to ablative local control of breast tumors is an emerging focus in breast cancer care. This study was performed to determine the feasibility and safety of treating small breast cancer with radiofrequency (RF) ablation.MethodsPatients with biopsy-proven invasive or non-invasive breast cancer underwent RF ablation under general anesthesia. Before RF ablation, all patients were confirmed to have a localized lesion using imaging modalities. Wide excision or total mastectomy with sentinel lymph node biopsy or axillary lymph node dissection was performed. The resected tumor was examined histologically with hematoxylin-eosin (H&E) and nicotinamide adenine dinucleotide-diaphorase (NADH) staining.ResultsTen patients completed the treatment without RF ablation-related complications. The mean tumor size was 1.1 cm (range: 0.5-2.0 cm). Histological evaluation of the ablated tissue using H&E staining revealed a spectrum of changes ranging from complete coagulation necrosis of tumor cells to normal-appearing tumor cells. However, NADH-diaphorase showed no staining of viable tumor cells in the RF-ablated region in all of the patients.ConclusionsRF ablation is promising as a minimally invasive ablation technique in the local treatment of invasive or non-invasive breast cancer. However, further study is necessary before RF ablation can replace conventional breast conservation therapy for patients with small breast cancer.(c) 2006 Wiley-Liss, Inc.

28 keywords...

hide…