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J. Am. Acad. Dermatol. · Nov 2009
Review Case ReportsAggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma).
- Mark Jean-Aan Koh, Sapna P Sadarangani, Yuin-Chew Chan, Mei-Yoke Chan, Ah-Moy Tan, Suat-Hoon Tan, Yong-Kwang Tay, and Siok-Bian Ng.
- Department of Dermatology, Changi General Hospital, Singapore. docmark@pacific.net.sg
- J. Am. Acad. Dermatol. 2009 Nov 1; 61 (5): 875-81.
AbstractSubcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.
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