• Omri Zamstein, Eyal Sheiner, Tamar Wainstock, Daniella Landau, and Asnat Walfisch.
• Goldman School of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: omrizam@post.bgu.ac.il.
• Diabetes Res. Clin. Pract. 2018 Jun 1; 140: 200-207.

AimsTo assess the implications of gestational diabetes mellitus (GDM) on long-term respiratory related hospitalizations of the offspring.MethodsA population-based cohort analysis including singleton pregnancies delivered between the years 1991 to 2014 in a tertiary referral hospital was conducted. Incidence of hospitalizations (up to age 18 years) due to various respiratory diseases was compared between offspring of GDM-complicated pregnancies and normoglycemic pregnancies. Kaplan-Meyer curves were used to assess cumulative hospitalization incidence. Cox proportional hazards model was used to control for baseline selected confounders.ResultsDuring the study period 216,197 deliveries met the inclusion criteria. Of those, 4.7% (n = 10,184) were complicated by GDM. In most of the investigated respiratory diseases, no significant differences were found between offspring of both groups. Nonetheless, obstructive sleep apnea-related hospitalization rate was higher among the GDM group, an association which proved to be independent of potential confounders with an adjusted hazard ratio of 1.26 (95% CI 1.02-1.55; p = 0.036).ConclusionGestational diabetes mellitus does not appear to be associated with long-term respiratory hospitalizations of the offspring other than obstructive sleep apnea-related hospitalizations.Copyright © 2018 Elsevier B.V. All rights reserved.

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