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Cancer Chemother. Pharmacol. · Aug 2001
ST1571, a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia: validating the promise of molecularly targeted therapy.
- M J Mauro, M E O'Dwyer, and B J Druker.
- Leukemia Program, Oregon Health Sciences University, Portland 97201, USA.
- Cancer Chemother. Pharmacol. 2001 Aug 1; 48 Suppl 1: S77-8.
AbstractThe deregulated tyrosine kinase activity of the Bcr-Abl fusion protein has been established as the causative molecular event in chronic myelogenous leukemia (CML). Thus the Bcr-Abl tyrosine kinase is an ideal target for pharmacologic inhibition. ST1571 (formerly CGP57148B), is an Abl-specific tyrosine kinase inhibitor that in preclinical studies selectively kills Bcr-Abl-containing cells in vitro and in vivo. The results of clinical studies have demonstrated the potential of molecularly targeted therapies, and ST1571 is emerging as a new therapeutic agent for CML.
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