• J. Child Neurol. · Dec 2014

    Case Reports

    Primary diffuse leptomeningeal gliomatosis mimicking tuberculous meningitis.

    • Muhammet Kosker, Dicle Sener, Omer Kilic, Zehra Isik Hasiloglu, Civan Islak, Ali Kafadar, Sebnem Batur, Buge Oz, Haluk Cokugras, Necla Akcakaya, and Yildiz Camcioglu.
    • Division of Infectious Diseases, Clinical Immunology and Allergy, Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    • J. Child Neurol. 2014 Dec 1; 29 (12): NP171-5.

    AbstractPrimary diffuse leptomeningeal gliomatosis is a disease with an aggressive course that can result in death. To date, 82 cases have been reported. Here, the case of a 3-year-old male patient presenting with strabismus, headache, and restlessness is reported. Physical examination revealed paralysis of the left abducens nerve, neck stiffness, and bilateral papilledema. Tuberculous meningitis was tentatively diagnosed, and antituberculosis treatment was initiated when cranial imaging revealed contrast enhancement around the basal cistern. Craniocervical magnetic resonance imaging (MRI) was performed when there was no response to treatment, and it revealed diffuse leptomeningeal contrast enhancement around the basilar cistern, in the supratentorial and infratentorial compartments, and in the spinal region. Primary diffuse leptomeningeal gliomatosis was diagnosed by a meningeal biopsy. © The Author(s) 2013.

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