• Am J Hosp Palliat Care · Nov 2004

    Review

    Changes in endocrine therapy: anastrozole and advanced breast cancer in postmenopausal women.

    • Jean-Marc Nabholtz.
    • Oncology Institute, American Hospital of Paris, Paris, France.
    • Am J Hosp Palliat Care. 2004 Nov 1; 21 (6): 457-65.

    AbstractEmerging data on endocrine therapies necessitates a re-evaluation of treatment strategies for advanced breast cancer. In this review, we present data from recent studies of the third-generation, nonsteroidal aromatase inhibitor (AI) anastrozole that illustrate its changing role in the treatment of postmenopausal women with advanced breast cancer. These studies demonstrate that anastrozole is now a treatment of choice as first-line therapy for patients presenting with advanced breast cancer and for patients who have progressed to advanced disease after adjuvant therapy with tamoxifen. A further trial has also shown that anastrozole is an effective and well-tolerated alternative to tamoxifen as adjuvant treatment for postmenopausal women with early breast cancer.

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