• Nucl Med Commun · Jan 2013

    Clinical Trial

    Is cerebral glucose metabolism affected by chemotherapy in patients with Hodgkin's lymphoma?

    • Agostino Chiaravalloti, Marco Pagani, Barbara Di Pietro, Roberta Danieli, Mario Tavolozza, Laura Travascio, Cristiana R Caracciolo, Giovanni Simonetti, Maria Cantonetti, and Orazio Schillaci.
    • Department of Biopathology and Diagnostic Imaging, University Tor Vergata cInstitute of Cognitive Sciences and Technologies, CNR, Rome, Italy. agostino.chiaravalloti@gmail.com
    • Nucl Med Commun. 2013 Jan 1; 34 (1): 57-63.

    ObjectiveThe aim of the study was to investigate the effect of chemotherapy treatment with ABVD on brain glucose metabolism in patients with Hodgkin's disease (HD).MethodsA total of 49 patients (23 men, 26 women; mean age 32±9 years) diagnosed with HD were included in the study. All of them underwent a baseline (PET0) and an interim (PET2) 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) PET/computed tomography (CT) brain scan. All patients were treated after PET0 with two cycles of ABVD consisting of doxorubicin (adriamycin), bleomycin, vinblastine, and dacarbazine for 2 months. Thirty-five patients were evaluated further 15±6 days after four additional cycles (PET6). Differences in brain (18)F-FDG uptake were analyzed by statistical parametric mapping (SPM2).ResultsCompared with PET0, PET2 showed a significantly higher metabolic activity in the right angular gyrus (Brodmann area 39) and a significant metabolic reduction in Brodmann areas 10, 11, and 32 bilaterally. All these changes disappeared at PET6.ConclusionOur results support the conclusion of a very limited impact of ABVD chemotherapy on brain metabolism in patients with HD.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…